This indicates an attempt to exploit one of several file download vulnerabilities in Macrovision FlexNext Connect.
The vulnerabilities can be exploited through the ActiveX Control "MVSNClientDownloadManager61Lib.DownloadManager". An attacker can create a specially crafted web page with an embedded call to the "AddFile()" method, causing a vulnerable host to silently download and execute a file.
DownloadManager object ISDM.exe version 22.214.171.124372
We are not aware of any update at this time. As a work around set the kill bit to block this ActiveX Control.